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Hello! I'm Vipul

I do research in the field of natural products based drug discovery using computational tools and techniques. Pursuing Doctor of Philosophy (Ph.D.) focused in Computational drug discovery from the Indian Institute of Technology, Delhi.

Vipul Kumar

Ph.D. Scholar at DAILAB, IIT Delhi.

Email:

vipul2732@gmail.com

vipul.kumar@dbeb.iitd.ac.in

Contact: +919592036780

+917986787044

(Whatsapp)

Address:

Indian Institute of Technology Delhi, India

Date of Birth:

August 29, 1995

My CV: Vipul_Kumar CV.pdf

EXPERIENCE

2019-2020

Teaching Assistant

Indian Institute of Technology Delhi

Teaching Assistant (TA) in the Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology. As a TA, I assisted the Professor in the lab sessions of undergraduate students in the subject of Bioinformatics and Computational Structural Biology.

June 2017- July 2017

Quality Control Microbiologist (Trainee)

Capsugel Healthcare Pvt. Ltd. (A Lonza Group)

Undergone four weeks of Industrial training at Capsule Healthcare Pvt. Ltd. as a trainee microbiologist under the department of quality control where I have learned about microbial limit testing of different In-Process and hard gelatin capsule shells according to the standard of Indian Pharmacopeia.

EDUCATION

2018- Present

Ph.D. in Computational Biology

Indian Institute of Technology Delhi, India

I joined the institute in 2018 in a Master's program, MS (Biochemical Eng. and Biotech). However, IIT Delhi, an institute of eminence, Government of India, provides flexibility to master's students to upgrade their degree based on the academic merit in the master's course work. Taking this opportunity I upgraded my degree from Masters to Ph.D. Further, I was able to complete the course work of the Ph.D. program with a grade of 8.06/10 and currently, I am involved in my research project under the guidance of Prof. Durai Sundar.

2014-2018

Bachelor of Technology (Biotechnology)

Lovely Professional University, Punjab

I did a four-year bachelor's degree in Biotechnology from LPU Punjab. I graduated with a CGPA of 8.8/10. I did my B.tech research project under the guidance of Prof. Manoj Jena, where I studied and compared the antimicrobial activity of Ocimum sanctum and Azadirachta indica .

Expertise

CLIENTS

I'M A Computational Biologist

Experienced in molecular modeling and CADD such as virtual ligand screening, computationally-driven lead optimization, ligand-based drug design, molecular dynamics, homology modeling, quantum mechanics, ADMET/QSPR.

SKILLS

Biomolecular modelling

Computational drug discovery

Molecular Dynamics Simulations

Bioinformatics tools and Databases

Microscopy, AGE, HPLC(Basics)

Cell culturing, DNA extraction

PEER REVIEWED PUBLICATIONS

EXPERTISE

Rathi, A.#, Kumar, V.# and Sundar, D. (2022). Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors. J. Biomolecular Structure and Dynamics.https://doi.org/10.1080/07391102.2022.2028679. # Joint first authors.

Malik, V., Kumar, V., Kaul, S. C., Wadhwa, R., & Sundar, D. (2021). Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study. Current Research in Structural Biology.https://doi.org/10.1016/j.crstbi.2021.11.004

Kumar, V., Singh, J., Hasnain, S.E. and Sundar, D. (2021). Possible link between higher transmissibility of Alpha, Kappa and Delta variants of SARS-CoV-2 and increased structural stability of its spike protein and hACE2 affinity. International Journal of Molecular Sciences 22(17): 9131.doi: https://doi.org/10.3390/ijms22179131
Dhanjal, J.K., Kumar, V., Garg, S., Subramani, C., Agarwal, S., …& Wadhwa, R. (2021). Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides. International journal of biological macromolecules.doi:https://doi.org/10.1016/j.ijbiomac.2021.06.015

Kalra, R. S., Kumar, V., Dhanjal, J. K., Garg, S., Li, X., Kaul, S. C., ... & Wadhwa, R. (2021). COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays. Journal of Biomolecular Structure and Dynamics, 1-14.doi:

10.1080/07391102.2021.1902858

Singh, J., Samal, J., Kumar, V., Sharma, J., Agrawal, U., Ehtesham, N. Z., ... & Hasnain, S. E. (2021). Structure-Function Analyses of New SARS-CoV-2 Variants B. 1.1. 7, B. 1.351 and B. 1.1. 28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications. Viruses, 13(3), 439. doi: https://doi.org/10.3390/v13030439
Sari, A. N., Elwakeel, A., Dhanjal, J. K., Kumar, V., Sundar, D., Kaul, S. C., & Wadhwa, R. (2021). Identification and Characterization of MortaparibPlus—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and-Independent Mechanisms. Cancers, 13(4), 835. doi: https://doi.org/10.3390/cancers13040835
Malik, V., Kumar, V., Kaul, S. C., Wadhwa, R., & Sundar, D. (2021). Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers. Biomolecules, 11(2), 160.doi: https://doi.org/10.3390/biom11020160
Kumar, V., Dhanjal, J.K., Kaul, A., Wang, J., Zhang, H., Bhargava, P. Kaul, S.C., Wadhwa, R. and Sundar, D. (2020). Withanone and Withaferin-A have ability to inhibit Transmembrane Protease Serine 2 (TMPRSS2) to block the entry of SARS-CoV-2 into the cells. J. Biomolecular Structure and Dynamics.doi:10.1080/07391102.2020.1775704
Kumar, V., Dhanjal, J. K., Kaul, S. C., Wadhwa, R., & Sundar, D. (2020). Withanone and Caffeic Acid Phenethyl Ester are Predicted to Interact with Main Protease (Mpro) of SARS-CoV-2 and Inhibit its Activity. Journal of Biomolecular Structure and Dynamics.doi: 10.1080/07391102.2020.1772108.
KUMAR, V., CHAKRABORTY, A., KAUR, M., PANDEY, S., & JENA, M. K. (2018). Comparative study on antimicrobial activity of tulsi (Ocimum sanctum) and neem (Azadirachta indica) methanol extract. Asian Journal of Pharmaceutical and Clinical Research, 11(12), 514-517. doi: 10.22159/ajpcr.2018.v11i12.28756.

CONTACT

Research work featured in Media

DAILAB RAUDIO Series-2 Episode 15- 200606 Kumar et al -Mpro and TMPRSS2Dr. Renu Wadhwa

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